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Buy Oxycodone 40mg Sandoz, Buy Oxycodone online HERE from the best online medicine store. Oxycodone Opioid Meds is the best online medicine store to order oxycodone online. However, oxycodone is a semi-synthetic opioid synthesized from thebaine, an opioid alkaloid found in the Persian poppy and one of the many alkaloids found in the opium poppy. It is a moderately potent opioid pain medication (orally about 1.5 times more potent than morphine), generally indicated for moderate to severe pain relief. Oxycodone is a pure opioid agonist whose main therapeutic action is analgesia.

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Other members of the class known as opioid agonists include substances such as morphine, hydromorphone, fentanyl, codeine, and hydrocodone. Pharmacological effects of opioid agonists include anxiolysis, euphoria, feeling relaxed, respiratory depression, constipation, miosis, and cough suppression, as well as analgesia. Like all pure opioid agonist analgesics. In conclusion, order oxycodone online to relieve your moderate or severe pain. A 215 footprint A 215 is blue, round and also supplied by Actavis. used in the treatment of chronic pain; pain and belongs to the class of narcotic analgesic drugs.

Recorded indications: Treatment of severe pain.

Active ingredient: oxycodone hydrochloride.
Pharmacological
properties Oxycodone is a semisynthetic opioid structurally related to morphine and codeine; Like morphine, it has a high affinity for Mu, Kappa and Delta receptors in the brain and spinal cord and is devoid of antagonistic properties.
Administered orally, it is well absorbed. The release of oxycodone from the tablets occurs in two phases, with a relatively fast initial release producing an onset of the early analgesic effect, followed by a more controlled release resulting in a duration of action of 12 hours1.

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Maximum plasma concentrations are reached after approximately 3 hours2. In the liver, oxycodone is metabolised by cytochrome P450 to noroxycodone and to a lesser extent to oxymorphone, which do not contribute to its analgesic effect and are eliminated in the urine3. The half-life is 4-5 hours. In the elderly, the clearance of oxycodone is only slightly reduced and does not require dosage adjustment.

Undesirable effects
The undesirable effects of controlled-release oxycodone are the same as those of oral morphine in incidence and type and include constipation, nausea and/or vomiting (25-30% of patients), sedation, dizziness and pruritus. Adverse reactions are typical of strong opioids and, except for constipation (which can be treated with appropriate laxatives), tend to decrease over time.

Warnings
Oxycontin tablets should be swallowed whole and should not be crushed or chewed. This warning is particularly important as taking broken tablets results in a rapid release of the active substance and absorption of a potentially lethal dose of oxycodone2,3.

Interactions
Like all opiates, oxycodone potentiates the central depressant effects of phenothiazines, tricyclic antidepressants, hypnotics, sedatives, and alcohol. Oxycodone metabolism may be reduced by cimetidine and other cytochrome P450 inhibitors such as azole antifungals (e.g., ketoconazole) and macrolides (particularly erythromycin). Conversely, P450 inhibitors such as quinidine can increase plasma concentrations and drug half-life2.

Dosage: 10 mg every 12 hours, to be increased, in increments of 25-50%, until pain is controlled. In patients with severe renal or hepatic impairment, the dosage or frequency of administration should be reduced.